In silico study of amyloid -protein folding and oligomerization
نویسندگان
چکیده
منابع مشابه
In silico study of amyloid -protein folding and oligomerization
Experimental findings suggest that oligomeric forms of the amyloid protein (A ) play a critical role in Alzheimer’s disease. Thus, elucidating their structure and the mechanisms of their formation is critical for developing therapeutic agents. We use discrete molecular dynamics simulations and a four-bead protein model to study oligomerization of two predominant alloforms, A 40 and A 42, at the...
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Oligomeric assemblies of the amyloid -protein (A ) have been implicated in the pathogenesis of Alzheimer’s disease as a primary source of neurotoxicity. Recent in vitro studies have suggested that a 10-residue segment, Ala-21–Ala-30, forms a turn-like structure that nucleates the folding of the full-length A . To gain a mechanistic insight, we simulated A (21–30) folding by using a discrete mol...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0408153101